Chimeric antigen receptor (CAR) T cells hold great promise for targeting and fighting cancer. However, their efficacy in solid tumors has been below expectations, as the tumor microenvironment (TME) limits their infiltration and produces a range of immune-inhibitory molecules to deactivate T cells. Researchers are developing new strategies to enhance CAR-T cell therapy for solid tumors by disrupting the TME and promoting T cell persistence. In this webinar brought to you by IsoPlexis, Katie McKenna will discuss how she uses CAR-T cells in combination with mesenchymal stromal cells that deliver engineered adenoviruses to stimulate the immune response in the TME.
Topics to be covered
Targeting non-small cell lung cancer using a cell carrier system to deliver an oncolytic and immunostimulatory adenovirus
Efficacy of oncolytic virotherapy in 3D cell culture and in vivo
Assessing T cell functionality with single-cell proteomics
Tuesday, April 27, 2021
2:30 - 3:30 PM Eastern Time
Meet the speaker
Katie McKenna, PhD Postdoctoral Fellow Center for Cell and Gene Therapy Baylor College of Medicine Texas Children’s Hospital Methodist Hospital
Harnessing Single-Cell Multi-Omic Energy States for Integrated Cancer Biology Feb 16, 2021
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