Systems Immunology: Understanding Responses to Vaccination and Infection

Systems immunology is a new and rapidly developing field of research providing quantitative molecular profiles of patients' immune responses, made possible by recent advances in multiple technological platforms. The human-centered approach has invigorated vaccine research and shown promise to enhance our knowledge of the systemic immune response to vaccination and infection that was not possible with classical, animal-model based approaches. Techniques that make use of peripheral blood to survey systemic immune responses include next-generation sequencing coupled to bioinformatic analysis, gene and protein microarrays, metabolomics, multiparameter flow cytometry, mass cytometry, and multiplex cytokine and chemokine assays. The Scientist is bringing together a panel of experts to present their research in systems immunology and provide insight into this exciting new field.

Topics to be Covered

New insights into immune responses to infection through data-driven analysis of multiplexed single-cell data
Using systems immunology to understand innate immune dysfunction in HIV infection

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Systems Immunology: Understanding Responses to Vaccination and Infection